CellStim Therapy speeds up wound healing by increasing capillary density and perfusion, improving wound oxygenation, and encouraging granulation and fibroblast activity.
References
Microcurrent Stimulation Triggers MAPK Signaling and TGF-β1 Release in Fibroblast and Osteoblast-Like Cell Lines
To summarize, our data show that ES, in the form of microcurrents, promotes the activation of ERK 1/2 and p38 in the cell types implicated in wound or fracture healing, increases the expression levels of Col1A1 and Mmp19, which are critical molecules for ulcers’ healing and upregulates TGF-β1, MAPKs and Hedgehog signaling pathways. Therefore, we confirmed that stimulation with microcurrents accelerates the healing process in vitro by triggering the phosphorylation of MAPKs ERK 1/2 and p38 and alters the transcriptome profile of the cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564311/
Electrical microcurrent stimulation therapy for wound healing: A meta-analysis of randomized clinical trials
Conclusions
The current meta-analysis supports the conclusion that incorporating EMT to SWC of acute and chronic wounds improves healing by reducing the wound area and time to complete healing, with moderate and low certainty in the evidence, respectively. Additionally, EMT reduces pain perception and has proven to be a safe technique with few minor side effects. The effect on the healing time can be of special importance in chronic wounds or those with greater healing problems.
https://www.sciencedirect.com/science/article/abs/pii/S0965206X21001327
Polarity reversal of microcurrent reinitiates wound repair processes following plateaus in healing. Blood coagulation and thrombosis occurs in the vessel beneath the anode but not beneath the cathode. When the polarity is reversed the cathode is capable of solubilizing the clot formed beneath the anode.
(Becker R. 1988)
Electrotherapy for Acceleration of Wound Healing: Low Intensity Direct Current
Carley and Wainapel, Archives of Physical Medicine and Rehabilitation, Vol. 66, July 1985
Summary: 30 hospital patients with non healing ulcers were divided into two groups, one treated with conventional wound dressings and one with microcurrent stimulation at 300-700 uA. The latter group was given two two hour stimulation periods per day. After six weeks of such treatments, the group treated with microcurrents showed a 150-250% faster healing rate , with stronger scar formation, less pain and lessened infection of the treated area.
Accelerated Healing of Skin Ulcers by Electrotherapy
Wolcott, Wheeler, Hardwicke, and Rowley Southern Medical Journal, July 1969.
Summary: Researchers applied microcurrent stimulation ranging from 200-800 uA to a wide variety of wounds, using negative polarity over the lesions in the initial phase, and then alternating positive and negative electrodes every three days. The treated group showed 200-350% faster healing rates than control, with stronger tensile strength of scar tissue and antibacterial effects in infected wounds in the treated group. Keywords: ulcers, polarity, stimulation, quadriplegia, healing
Use of Low Intensity Direct Current in Management Ischemic Skin Ulcers
Gault and Gatens: Physical Therapy, Vol. 56, #3, March 1976.
Summary: 100 patients with skin ulcers were treated with microcurrent stimulation; six of them had bacterial ulcers with one side used as controls. Stimulation of 200-800 uA was applied, with negative polarity used until infection cleared, and then polarity reversed. Patients had diagnosis ranging from quadriplegia, CVA, brain tumor, peripheral vascular disease, burns, diabetes, fracture, and amputation. The lesions with patients treated with currents showed approximately twice as fast a healing rate.
Keywords: accelerated, wound healing, current, ATP, amino acids, biochemical
Effects of Electrical Microcurrents on Regeneration Processes in Skin Wounds
Sinitsyn, Razvozva, Ortop Travmatol Protez, Feb. 1986
Summary: 68 patients with post burn and post traumatic wounds underwent treatment constant and modulated microcurrent of negative polarity of 1-10 uA/cm2 over a period of 2-20 days. Although both groups showed accelerated regeneration, the modulated electric current group showed more prolonged and marked effect. Better survival of skin grafts was demonstrated compared with untreated patients.
